Three hundred Black and Latinx teens in Chicago will be recruited to participate in the first clinical trial to measure the potential health benefits of youth-driven racial justice activism. The five-year study, funded by a $3.8 million grant from the National Institute on Minority Health and Health Disparities, will assess whether activism can lower depression symptoms in minoritized teens, as well as alter physiological factors known to be increased with exposure to racism, such as blood pressure and markers of stress and inflammation in the blood.