A five-year study on men that had just the cancerous portion of their prostate glands destroyed shows that the procedure averted cancer recurrence in most patients while preserving urinary and sexual function.

Researchers studying British Labrador retrievers have identified multiple genes associated with canine obesity and shown that these genes are also associated with obesity in humans.

Women with higher levels of essential minerals circulating in their blood during pregnancy, particularly copper and manganese, along with vitamin B12, had a lower risk of developing high blood pressure in middle age, about 20 years later, according to research presented at the American Heart Association's Epidemiology and Prevention | Lifestyle and Cardiometabolic Health Scientific Sessions 2025.

Asian American, Native Hawaiian and other Pacific Islander (AANHPI) populations experienced differences in both cardiovascular disease predicted risk and risk factors, according to preliminary research presented at the American Heart Association's Epidemiology and Prevention | Lifestyle and Cardiometabolic Health Scientific Sessions 2025.

Investigators have found that the gene Asah1 plays a crucial protective role in preventing the progression of nonalcoholic fatty liver diseases (NAFLD) into more severe forms of liver disease by regulating hepatic lipid homeostasis and cellular maintenance processes.

The microbiome shapes development of insulin-producing cells in infancy, leading to long-term changes in metabolism and diabetes risk, new research in mice has found.

UCSF researchers are the first to demonstrate that the approach works for the patients who need it the most.

It is estimated that around 80 million people worldwide live with a tremor. For example, those who live with Parkinson's disease.

A recently launched Phase 1 clinical trial at Mass General Brigham is examining the safety and feasibility of a groundbreaking treatment approach for Parkinson's disease in which a patient's stem cells are reprogrammed to replace dopamine cells in the brain damaged by the disease.

Teenagers who do not get the recommended amount of sleep may be at an increased risk for high blood pressure, according to preliminary research presented at the American Heart Association's Epidemiology, Prevention, Lifestyle & Cardiometabolic Health Scientific Sessions 2025.

Researchers have discovered a novel approach to protecting insulin-producing beta cells from the damaging effects of glucolipotoxicity - a harmful condition linked to the progression of type 2 diabetes (T2D). These findings could lead to promising treatments targeting beta cell dysfunction.

Most obese patients grow resistant to satiety signals from the hormone leptin. A new study shows that leptin sensitivity can be restored in mice, leading to weight loss.

Gut microbes that were thought to feed exclusively on dietary fiber also get fed sugar from our guts, from which they produce short-chain fatty acids that are crucial to many body functions. The discovery of this symbiotic relationship also points the way to developing novel therapeutics.

Researchers have discovered a new way in which the liver regulates its consumption of sugar and fat. This could potentially increase the effectiveness of weight-loss and diabetes medication.

A study has provided new insights into the role of the brain as a crucial control center and the origin of obesity and type 2 diabetes. The hormone insulin plays a key role in the development of obesity. The brain's sensitivity to insulin is associated with long-term weight gain and unhealthy body fat distribution. What specific functions does insulin perform in the brain, and how does it affect individuals of normal weight?

A new study details the discovery of rare gene variants that increase the prevalence of Type 2 diabetes in multiple generations of Asian Indian people. The unusual finding is a step toward more targeted treatment for all people with Type 2 diabetes, a disease with complex genetic influences.

Researchers are investigating whether certain viruses known as bacteriophages, or phages, which specifically infect bacteria but not human cells, affect the development of type 1 diabetes in young children.

A healthy diet in early pregnancy supports the child's motor development at the age of 5-6 years. Higher maternal body fat mass, on the other hand, has an adverse effect on the child's motor development.

Researchers have found that people with diabetes can achieve the same positive results using advanced insulin technology when trained by their primary care providers (PCPs) or through telehealth as they would by seeing a specialist in person.

Diabetes and obesity have become pressing health issues worldwide. Glucagon-like peptide-1 (GLP-1) receptor agonists, a class of medications widely used in the treatment of type 2 diabetes (T2D), have shown significant effectiveness in both lowering blood sugar levels and aiding weight loss due to their unique pharmacological mechanisms. A research team assessed the impact of GLP-1 receptor agonist in weight loss through genetic studies, aiming to understand whether the use of these medications reduces weight due to muscle or fat mass loss. This genetic study revealed that GLP-1 receptor agonists reduce weight by reducing more fat mass than muscle mass.

Adding engineered human blood vessel-forming cells to islet transplants boosted the survival of the insulin-producing cells and reversed diabetes in a preclinical study. The new approach, which requires further development and testing, could someday enable the much wider use of islet transplants to cure diabetes.

Insulin resistance precedes and predicts the onset of type 2 diabetes mellitus (DM2), a chronic disease that causes high morbidity and mortality worldwide. In affected people, insulin is unable to facilitate the uptake of glucose through tissues and organs, leading to an increase in blood glucose (chronic hyperglycaemia). Since skeletal muscle is the tissue that uses the most glucose in response to insulin action, it is the most affected tissue by insulin resistance.

New research shows sotagliflozin is the only drug in its class to demonstrate these results.

A recent study reveals that age plays a significant role in the outcomes of intermittent fasting. Researchers discovered that chronic intermittent fasting disrupted the development of insulin-producing beta cells in young mice. The findings raise concerns about potential risks for humans, especially teenagers.

Researchers have developed a new gene switch that can be activated using a commercially available nitroglycerine patch applied to the skin. One day, researchers want to use switches of this kind to trigger cell therapies for various metabolic diseases.

The chemical compound sulforaphane found in broccoli sprouts can be linked to improved blood sugar levels in prediabetes, a precursor to type 2 diabetes. The broccoli compound had a more significant effect on blood sugar levels in certain people.

Researchers have proven that antibiotic-resistant strains of a harmful bacteria thrive in a diabetic infection environment.

People with type 1 diabetes require continuous insulin treatment and must regularly measure their glucose levels. With open-loop therapies, insulin administration is manually controlled, while hybrid closed-loop systems automatically regulate insulin delivery. A study showed that hybrid closed-loop systems offer improved long-term blood sugar values (HbA1c levels) and a lower risk of hypoglycemic coma, but lead to a higher rate of diabetic ketoacidosis.

Mitochondria are essential for generating energy that fuels cells and helps them function.

The research found that heavy drinkers with either diabetes, high blood pressure or a high waist circumference are as much as 2.4 times more likely to develop advanced liver disease.

How does the body regulate the activity of insulin-producing cells in order to react quickly to changing conditions? Researchers have investigated this question.

Drinking ketones improves heart health, a new small-scale study has found.

Body-weight cycling (also known as yo-yo dieting) has been shown to significantly increase the risk of kidney disease in people with type 1 diabetes, regardless of body mass index (BMI) and other traditional risk factors, according to a new study.

It's well known that consuming sugary drinks increases the risk of diabetes, but the mechanism behind this relationship is unclear. Now researchers show that metabolites produced by gut microbes might play a role. In a long-term cohort of US Hispanic/Latino adults, the researchers identified differences in the gut microbiota and blood metabolites of individuals with a high intake of sugar-sweetened beverages. The altered metabolite profile seen in sugary beverage drinkers was associated with a higher risk of developing diabetes in the subsequent 10 years. Since some of these metabolites are produced by gut microbes, this suggests that the microbiome might mediate the association between sugary beverages and diabetes.

A diabetes drug may beat costly shots for patients with a rare genetic condition, according to a Rutgers Health study.

Scientists have shown that specialized cells involved in how the body responds to insulin are activated in the brain after exercise, suggesting that physical activity may directly improve brain function.

People whose parents divorced during their childhood may be at a greater risk of stroke later in life, according to a new study.

Data from continuous glucose monitors can predict nerve, eye and kidney damage caused by type 1 diabetes researchers have found. That suggests doctors may be able to use data from the devices to help save patients from blindness, diabetic neuropathy and other life-changing diabetes complications.

A team of researchers discovered that combining neuromuscular electrical stimulation with resistance training results in greater muscle mass and strength compared to resistance training alone.

Scientists have conducted a pioneering study on the benefits of intermittent fasting. Not eating anything from 5 p.m. until 9 a.m. the following day (early fasting) helps to a greater extent to improve blood sugar regulation and reduce abdominal subcutaneous fat, i.e. the fat just under the skin.

A study has found cardiovascular conditions such as high blood pressure and diabetes, which are known to contribute to brain blood vessel damage in younger populations, not to be associated with an increased risk of such harm in individuals 90 and older.

Researchers have studied placental genes to explore how Assisted Reproductive Technology (ART) affects a child's development. Differences showed up between pregnancies from frozen and fresh embryo transfers in the placentas. Changes were also observed in the function of a gene associated with obesity and type 2 diabetes.

Until now, scientists have been unable to determine how metformin, a Type 2 diabetes medication that lowers blood sugar, works. A study provided direct evidence in mice that it reversibly cuts the cell's energy supply by interfering with mitochondria to lower glucose levels.

Researchers studied oxygen treatment as a potential therapy to target specific cells linked to the development of cardiovascular and metabolic disorders like high blood pressure and type 2 diabetes and found no significant improvement in function in patients with type 2 diabetes.

Endocannabinoids in the brain play a key role in food intake and energy use. Modulating the action of these molecules could help fight obesity, say researchers.