Spinal muscular atrophy (SMA) is a severe neurological disease for which there is presently no cure, although current therapies can alleviate symptoms. In the search for better treatment options, scientists at DZNE and the Dresden University of Technology are now drawing attention to previously unnoticed abnormalities in embryonic development. They base their argument on studies of so-called organoids: Laboratory-grown tissue cultures that can reconstruct disease processes. Their findings are published in the journal Cell Reports Medicine.

Children with special health care needs (CSHCN) often face significant disruptions in their education due to extended hospitalizations. A recent study published online in Disability and Rehabilitation on July 1, 2024, by a multidisciplinary team of Kessler Foundation and Children Specialized Hospital.

In November 2021, Northwestern University researchers introduced an injectable new therapy, which harnessed fast-moving "dancing molecules," to repair tissues and reverse paralysis after severe spinal cord injuries.

A combination of two drugs was capable of suppressing tumors in a non-conventional manner. Instead of inhibiting tumor cell division, as the most widely used medications do, the strategy consisted of hyperactivating oncogenic signaling by these cells to the point where they became stressed.

Many people with stage II or III colon cancer receive additional, or adjuvant, chemotherapy following surgery. However, clinical trials have shown that this treatment doesn't improve the chances of survival for every patient. A study published July 25th, 2024 in Cell Reports Medicine identifies and validates a 10-gene biomarker that potentially predicts whether a stage II or III colon cancer patient will benefit from adjuvant chemotherapy.

Researchers at UCLA Health uncovered new information about the role inflammation plays in mitigating liver fibrosis, which is associated with metabolic-associated fatty liver disease (MAFLD), one of the most common diseases in the world affecting up to 40 percent of U.S. adults. While inflammation in the liver has long been considered a prerequisite to developing liver fibrosis, the scarring and thickening of tissue that can impair the liver's ability to function, this new research suggests that reducing inflammation may not influence the extent of fibrosis.

Shibazuke is a traditional Japanese eggplant pickle produced by the process of fermentation using lactic acid bacteria (LAB). LAB which is commonly present in vegetables causes the spontaneous fermentation of vegetables, resulting in the distinctive acidic flavor of pickles. While LAB is beneficial, other species of bacteria and microbes that may be present in the food source can affect the food quality and safety. Advancements in the areas of food technology and nutrition have allowed the large-scale fermentation of pickles via industrial fermenters, where conditions that affect fermentation like temperature, pH-acid levels, and salt content are closely monitored.

New research to be presented at this year's Annual Meeting of the European Association for the Study of Diabetes (EASD) (Madrid, 9-13 September) shows that a child is almost twice as likely to develop type 1 diabetes (T1D) if their father has the condition than if their mother has the condition.

More and more studies show that men face risks of cancer from BRCA1 and BRCA2 genetic mutations that are most often associated with breast and ovarian cancers in women.

Low-income communities are up to 42% less likely to obtain stroke center certification.

New research shows that a certain bug, Alcaligenes faecalis (A. faecalis), can facilitate healing of hard-to-treat wounds among people with diabetes. While there are many studies done on potentially harmful bacteria in wounds, the researchers discovered that A. faecalis, a bacterium found in many types of chronic wounds, actually boosts healing of diabetic wounds. The researchers found that the beneficial bacterium can promote skin cell movements that are essential for wound closure by inhibiting enzymes that are over-produced in people with diabetes.

One of the easiest ways to improve your diet is to learn how to identify the most unhealthy foods to eat — and how to replace them with better options.

Current medical guidelines recommend that people in a preliminary stage of type 2 diabetes lose at least 7 percent of their body weight in order to prevent manifest diabetes. Diabetes experts advocate glycemic remission (normalization of blood sugar regulation) as a prevention goal for people with prediabetes or a high risk of type 2 diabetes. The article's claim is supported by numerous international scientists as well as by the DZD's Prevention Academy.Current medical guidelines recommend that people in a preliminary stage of type 2 diabetes lose at least 7 percent of their body weight in order to prevent manifest diabetes. In an article in 'Nature Reviews Endocrinology,' diabetes experts Prof. Andreas Birkenfeld and Prof. Viswanathan Mohan advocate glycemic remission (normalization of blood sugar regulation) as a prevention goal for people with prediabetes or a high risk of type 2 diabetes. The article's claim is supported by numerous international scientists as well as by the DZD's Prevention Academy.

Adolescents with severe obesity who received meal-replacement therapy plus financial incentives experienced a greater reduction in body mass index compared to those who received meal replacement therapy alone, according to recent findings.

A new once-weekly insulin has been approved in Europe and elsewhere, but it's not coming to the United States — at least not yet.

Just about the lightest sorbet you can imagine, with almost no carbs.

Persistently unhealthy sleep, either not enough or too much, is associated with a significantly increased risk of Type 2 diabetes in a racially and economically diverse adult population, an international team of researchers has reported.

People with diabetes face disapproval and discrimination. Here's what we can do about it.

A new GLP-1 drug in development helps preserve muscle during weight loss — but may not help your blood sugar.

High-protein diets, known as 'Paleolithic diets', are popular. Using mouse models, scientists have studied their impact. While effective in regulating weight and stabilizing diabetes, these diets are not without risks. Excess protein greatly increases ammonium production, overwhelming the liver. Excess ammonium can cause neurological disorders and, in severe cases, lead to coma. These results suggest caution when following these diets.

Pet cats may be excellent animal models for the study of obesity origins and treatment in humans, a new study of feline gut microbes suggests -- and both species would likely get healthier in the research process, scientists say.

Researchers have found that middle-aged to older adults with inconsistent sleep duration had a heightened risk of developing diabetes compared to those with more consistent sleep patterns.

Rigorous exercise before bed has long been discouraged, but researchers have now found short bursts of light activity can lead to better sleep.

Researchers reveal how a gene called SH2B1 works in the brain to regulate food intake.

At-home A1C tests are less accurate than lab tests but can still be beneficial for diabetes management.

A new study confirms that Afrezza works for some people with type 1 diabetes but not others.

Marinated in a beautiful marinade made with bright citrus juice, rich spices, fresh cilantro, and oil, these pork chops are always flavorful, juicy and tender.

A study found distinct signatures in CD8-positive T cells in blood samples from children with newly diagnosed type 1 diabetes and in autoantibody-positive children who later developed type 1 diabetes.

Switching from a diet high in saturated animal fats to one rich in plant-based unsaturated fats affects the fat composition in the blood, which in turn influences long-term disease risk. A study shows that it is possible to accurately measure diet-related fat changes in the blood and directly link them to the risk of developing cardiovascular disease and type 2 diabetes.

Investigators analyzing the potential cognitive effects of antidiabetic medications in records of more than 1.5 million patients with type 2 diabetes mellitus (T2DM) found risks of dementia and Alzheimer's disease (AD) were significantly lower in patients treated with metformin and sodium glucose co-transporter-2 inhibitors (SGLT-2i) compared to other antidiabetic drugs.

People who take injectable drugs that suppress appetite may be tempted to miss a dose before a special meal or vacation. But experts advise caution.

In preclinical studies, a team of researchers report new findings on a therapeutic combination that regenerated human insulin-producing beta cells, providing a possible new treatment for diabetes.

The chemical bisphenol A, found in plastic and metal food packaging, interferes with insulin signaling and may contribute to type 2 diabetes.

Individuals diagnosed with prediabetes can reduce their long-term risk of death and diabetes-related health complications if they delay the onset of diabetes for just four years through diet and exercise, according to new findings.

New research shows combined use of sodium glucose co-transporter 2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP1-RAs) is likely to offer additional protection against heart and kidney disease in patients with diabetes.

Reducing consumption of processed meat by around one-third could prevent more than 350,000 cases of diabetes in the US over 10 years.

A team has developed the most comprehensive epidemiological dataset for youth diabetes and prediabetes research, derived from extensive National Health and Nutrition Examination Survey (NHANES) data collected from 1999 to 2018. The dataset, revealed through the newly launched Prediabetes/diabetes in youth ONline Dashboard (POND), aims to ignite a new wave of research into the escalating issue of diabetes among young people.

A colder nose and warmer cheeks may be a telltale sign of rising blood pressure. Researchers discovered that temperatures in different face regions are associated with various chronic illnesses, such as diabetes and high blood pressure. These temperature differences are not easily perceptible by one's own touch but can instead be identified using specific AI-derived spatial temperature patterns that require a thermal camera and a data-trained model. With further research, doctors could one day use this simple and non-invasive approach for early detection of diseases.

When it comes to managing blood sugar levels, most people think about counting carbs. But new research shows that, for some, it may be just as important to consider the proteins and fats in their diet. The study is the first large-scale comparison of how different people produce insulin in response to each of the three macronutrients: carbohydrates (glucose), proteins (amino acids) and fats (fatty acids). The findings reveal that production of the blood sugar-regulating hormone is much more dynamic and individualized than previously thought, while showing for the first time a subset of the population who are hyper-responsive to fatty foods.

People with prediabetes are advised to reduce their weight in order to prevent manifest diabetes. Researchers have now been able to show that people achieve the best diabetes protection when they reduce their weight and at the same time normalize blood sugar regulation.

Dementia risk factors associated with cardiovascular health may have increased over time compared to factors such as smoking and having less education, finds a new study.

Type 2 diabetes in young people ages 10 to 19 has more than doubled in the past 20 years, yet it remains difficult for physicians to predict who will be diagnosed and who will improve with treatment. A new study shows that measuring the circulating abundance of microRNAs -- which affect insulin-producing beta cells in the pancreas -- is likely as effective as measuring the level of sugar in the blood for determining how a young person with the condition will fare.

Semaglutide, a medication initially developed for type 2 diabetes and obesity, significantly improves symptoms in men and women with a common type of heart failure that has had few therapeutic options. Women experienced greater weight loss and the same symptom benefits compared with men.

A wearable health monitor can reliably measure levels of important biochemicals in sweat during physical exercise. The 3D-printed monitor could someday provide a simple and non-invasive way to track health conditions and diagnose common diseases, such as diabetes, gout, kidney disease or heart disease. The monitor was able to accurately monitor the levels of volunteers' glucose, lactate and uric acid as well as the rate of sweating during exercise.

Fatty liver disease (steatotic liver disease, SLD for short) is increasingly causing failure of the liver as a vital organ. A team led by researchers has now discovered that a saturated fatty acid in blood vessels leads to the production of the signalling molecule SEMA3A, which closes the 'windows' in the blood vessels. This hinders the transport of fat from the liver to the adipose tissue. The researchers report that the windows open again and the fat in the liver is reduced when SEMA3A is inhibited.