Skin microbes do more than coexist—they shape immune responses, repair tissue, and influence gene expression across your lifespan. This review explains how disruptions in this microbiome-immune dialogue can lead to eczema, psoriasis, or acne.

Precancerous pancreatic lesions and some pancreatic ductal adenocarcinoma (PDAC) tumors harboring KRAS mutations had higher-than-normal expression of the FGFR2 protein, and FGFR2 inactivation delayed KRAS-mutated PDAC development in mice.

NIH-supported study reveals new risk group for future high blood pressure, heart disease.

Older adults experience less muscle soreness following exercise according to research which overturns the widespread belief that aging muscles are less resilient.

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Coronary heart disease (CHD), the most common cause of mortality globally, poses a formidable challenge to modern healthcare systems.

Inherited retinal degeneration (IRD) encompasses various disorders characterized by progressive loss of retinal photoreceptor cells, ultimately leading to vision loss and blindness.

The endoplasmic reticulum (ER) is the portion of the cell responsible for manufacturing and folding proteins.

Alzheimer's disease, the most common cause of dementia, is currently incurable. The current drugs available have very limited efficacy and only in mild stages of the disease.

The United States Food and Drug Administration (US FDA) has approved VYKAT™ XR, a significant milestone as the first approved treatment for hyperphagia in Prader-Willi syndrome (PWS).

Alcohol harm costs NHS England £3.5 billion annually, with 70 people dying every day from alcohol-related causes in the UK.

Nearly 40% of patients diagnosed with type 2 diabetes imperil their health by stopping their medication within the first year, diabetes experts warn.

A research team has investigated structural changes in kidneys of patients with hypertension and type 2 diabetes. The results show that high blood pressure can lead to abnormalities in the podocytes, specialized cells in the renal filter, even without other pre-existing conditions such as diabetes. The results underline the importance of early detection and consistent treatment of high blood pressure in order to prevent kidney damage.

Wearable mobile health technology could help people with Type 2 Diabetes (T2D) to stick to exercise regimes that help them to keep the condition under control, a new study reveals. An international team studied the behavior of recently-diagnosed T2D patients in Canada and the UK as they followed a home-based physical activity program, with some participants wearing a smartwatch paired with a health app on their smartphone.

A research team says high blood sugar levels appear to weaken function in key part of brain, mimicking Alzheimer's.

Scientists used advanced data analysis and machine learning to identify the viral proteins that may trigger autoimmune disorders such as type 1 diabetes and rheumatoid arthritis.

In 2010, a researcher was pouring over research data when he discovered something he thought was odd: His data showed that at 6 months of age, formula-fed babies born of mothers who were categorized as medically obese weighed about 5% units less fat than breastfed babies in the same dataset. That discovery struck him as unusual and led him on a research journey to better understand breast milk. Now, he's studying the connections between maternal gestational diabetes, breastfeeding and infant health.

Exposure to antibiotics during a key developmental window in infancy can stunt growth of insulin-producing cells in the pancreas and may boost risk of diabetes later in life, new research in mice suggests. The study also pinpoints specific microorganisms that may help those critical cells proliferate.

An innovative platform replicates pancreatic functions, transforming diabetes therapy.

Researchers show that using continuous glucose monitors can help measure glucose accurately during DKA and potentially prevent ICUs from being overwhelmed.

When mothers eat a diet high in fat and sugars, their unborn babies can develop liver stress that continues into early life. A new study sheds light on changes to the fetus's bile acid, which affects how liver disease develops and progresses.

Although there is no cure, diabetic retinal disease treatment has improved over the past two decades.

A sedentary lifestyle such as watching TV (two or more hours daily) may be a key factor in the risk of developing heart and blood vessel diseases, according to an analysis of health records from a large biomedical database.

New research suggests that automated insulin delivery (AID) systems are safe and effective for use by older adults with type 1 diabetes. The findings counter common assumptions that older adults would struggle to use the more advanced technology employed in the medical devices.

A Japanese study has found that the use of continuous glucose monitoring (CGM) devices, equipped with sensors that alert diabetics when their blood sugar levels drop, can potentially make diabetic drivers safer on the road. Those who used the devices had lower incidences of low blood sugar and reported increased confidence in driving.

The microbiome shapes development of insulin-producing cells in infancy, leading to long-term changes in metabolism and diabetes risk, new research in mice has found. The results could ultimately help doctors reduce the risk of type 1 diabetes -- or potentially even restore lost metabolic function in adulthood -- by providing specific gut microbes that help the pancreas grow and heal.

More than 120 million Americans suffer from diabetes or pre-diabetes. Triple-negative breast cancer (TNBC) is the most aggressive form of breast cancer, and TNBC patients with obesity-driven diabetes often have worse outcomes. A new study helps explain why this happens and suggests a potential way to improve treatment for these patients.

Research shows that a common type of diabetes medication could help cancer patients make a better long-term recovery. Many cancer patients go on to develop heart failure -- because of the cancer itself and also due to chemotherapy. But a study shows that a type of diabetes drug, called an SGLT2 inhibitor, may help protect the heart during and after cancer treatment. The medication has been shown to be beneficial in reducing heart failure or heart failure hospitalisation in cancer patients and survivors.

Researchers have discovered a novel approach to protecting insulin-producing beta cells from the damaging effects of glucolipotoxicity - a harmful condition linked to the progression of type 2 diabetes (T2D). These findings could lead to promising treatments targeting beta cell dysfunction.

Most obese patients grow resistant to satiety signals from the hormone leptin. A new study shows that leptin sensitivity can be restored in mice, leading to weight loss.

Gut microbes that were thought to feed exclusively on dietary fiber also get fed sugar from our guts, from which they produce short-chain fatty acids that are crucial to many body functions. The discovery of this symbiotic relationship also points the way to developing novel therapeutics.

Researchers have discovered a new way in which the liver regulates its consumption of sugar and fat. This could potentially increase the effectiveness of weight-loss and diabetes medication.

A study has provided new insights into the role of the brain as a crucial control center and the origin of obesity and type 2 diabetes. The hormone insulin plays a key role in the development of obesity. The brain's sensitivity to insulin is associated with long-term weight gain and unhealthy body fat distribution. What specific functions does insulin perform in the brain, and how does it affect individuals of normal weight?

A new study details the discovery of rare gene variants that increase the prevalence of Type 2 diabetes in multiple generations of Asian Indian people. The unusual finding is a step toward more targeted treatment for all people with Type 2 diabetes, a disease with complex genetic influences.

Researchers are investigating whether certain viruses known as bacteriophages, or phages, which specifically infect bacteria but not human cells, affect the development of type 1 diabetes in young children.

A healthy diet in early pregnancy supports the child's motor development at the age of 5-6 years. Higher maternal body fat mass, on the other hand, has an adverse effect on the child's motor development.

Researchers have found that people with diabetes can achieve the same positive results using advanced insulin technology when trained by their primary care providers (PCPs) or through telehealth as they would by seeing a specialist in person.

Diabetes and obesity have become pressing health issues worldwide. Glucagon-like peptide-1 (GLP-1) receptor agonists, a class of medications widely used in the treatment of type 2 diabetes (T2D), have shown significant effectiveness in both lowering blood sugar levels and aiding weight loss due to their unique pharmacological mechanisms. A research team assessed the impact of GLP-1 receptor agonist in weight loss through genetic studies, aiming to understand whether the use of these medications reduces weight due to muscle or fat mass loss. This genetic study revealed that GLP-1 receptor agonists reduce weight by reducing more fat mass than muscle mass.

Adding engineered human blood vessel-forming cells to islet transplants boosted the survival of the insulin-producing cells and reversed diabetes in a preclinical study. The new approach, which requires further development and testing, could someday enable the much wider use of islet transplants to cure diabetes.

Insulin resistance precedes and predicts the onset of type 2 diabetes mellitus (DM2), a chronic disease that causes high morbidity and mortality worldwide. In affected people, insulin is unable to facilitate the uptake of glucose through tissues and organs, leading to an increase in blood glucose (chronic hyperglycaemia). Since skeletal muscle is the tissue that uses the most glucose in response to insulin action, it is the most affected tissue by insulin resistance.

New research shows sotagliflozin is the only drug in its class to demonstrate these results.

A recent study reveals that age plays a significant role in the outcomes of intermittent fasting. Researchers discovered that chronic intermittent fasting disrupted the development of insulin-producing beta cells in young mice. The findings raise concerns about potential risks for humans, especially teenagers.

Researchers have developed a new gene switch that can be activated using a commercially available nitroglycerine patch applied to the skin. One day, researchers want to use switches of this kind to trigger cell therapies for various metabolic diseases.

The chemical compound sulforaphane found in broccoli sprouts can be linked to improved blood sugar levels in prediabetes, a precursor to type 2 diabetes. The broccoli compound had a more significant effect on blood sugar levels in certain people.

Researchers have proven that antibiotic-resistant strains of a harmful bacteria thrive in a diabetic infection environment.

People with type 1 diabetes require continuous insulin treatment and must regularly measure their glucose levels. With open-loop therapies, insulin administration is manually controlled, while hybrid closed-loop systems automatically regulate insulin delivery. A study showed that hybrid closed-loop systems offer improved long-term blood sugar values (HbA1c levels) and a lower risk of hypoglycemic coma, but lead to a higher rate of diabetic ketoacidosis.