A meta-analysis of 46 cohorts involving 611,037 to 1.14 million participants identified 1,260 lead genetic variants associated with the Big Five personality traits, including 824 in previously unlinked genomic regions.…

This review finds that obesity is linked to reciprocal interactions between diet, the gut microbiome, microbial metabolites, and host metabolic pathways that influence appetite, insulin sensitivity, inflammation, and energy balance…

Professional UFC fighters followed highly structured dietary patterns around competition, sharply restricting carbohydrates, fiber, fluids, and sodium before weigh-in before rapidly increasing carbohydrate, fluid, and sodium intake afterward. Despite aggressive…

In January 2026, Tim Andrews, who had received a genetically edited pig kidney in January 2025, became the recipient of a human kidney.

A targeted perspective synthesizes epidemiological and mechanistic evidence examining how caffeine consumption during midlife may influence dementia risk later in life. The authors highlight potential roles for dose, age, CYP1A2…

Late-life semaglutide treatment slowed age-related physiological decline, attenuated multiple molecular hallmarks of aging, and extended median lifespan from 742 to 834 days in aged female mice. The drug reproduced many…

Global disease burden is shifting toward aging-related conditions as people live longer, with these diseases now representing the largest expected lifetime health burden for newborns across all income groups. Modeling…

The Sussex 4-Day Week study is a 14-week UK protocol designed to investigate how reduced working hours affect physical and mental health, wellbeing, sleep, work performance, and potential biological and…

In a randomized crossover study of 22 healthy, normal-weight Chinese men, consuming canola oil alone or with spinach before a high-glycemic mashed-potato meal produced flatter post-meal glucose and insulin responses…

Researchers at the University of Oulu have identified alpha-1 antitrypsin as a potential target for preventing spontaneous preterm birth.