Tirzepatide enhances weight loss with sustained treatment but discontinuation leads to weight regain

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The current class of anti-obesity drugs is proving remarkably effective at removing excess pounds. However, a phase 3 randomized clinical trial found that people who stopped taking the medication regained…

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Study could pave the way for synergistic therapeutic combinations to better treat SF3B1-mutant MDS

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A new study from researchers with Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine and collaborating organizations provides insight into the underlying mechanisms of gene…

Continue ReadingStudy could pave the way for synergistic therapeutic combinations to better treat SF3B1-mutant MDS

Targeted therapy reduces markers of disease burden, improves symptoms for patients with nonadvanced system mastocytosis

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The targeted therapy bezuclastinib was safe and rapidly reduced markers of disease burden while also improving symptoms for patients with a rare blood disorder called nonadvanced system mastocytosis, according to…

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New drug combination doubles effectiveness in shrinking enlarged spleens in myelofibrosis patients

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Combining the JAK inhibitor ruxolitinib with the BCL-xL inhibitor navitoclax was twice as effective in reducing enlarged spleens – a major indicator of clinical improvement – compared with standard-of-care ruxolitinib…

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