A systematic review and meta-analysis of 15 studies found that ketogenic diets were associated with short-term reductions in body weight, waist circumference, insulin resistance, and some reproductive hormones in women with polycystic ovary syndrome, primarily among those with overweight or obesity.
However, substantial heterogeneity, low certainty of evidence, limited safety reporting, and short follow-up periods mean the clinical effectiveness and long-term sustainability of ketogenic diets in PCOS remain uncertain.