Scientists target NOX4 protein in skeletal muscle to combat aging
The powerful role of exercise in maintaining skeletal muscle could be the key to improving health and resilience in older age, according to new research from Monash University.
One drink a day may be the new upper limit for safer alcohol guidance
A US cause-specific modeling study found no net protective health effect from low-level alcohol consumption, with lifetime alcohol-attributable mortality risk rising above 1 in 1,000 at just over 6.5 drinks…
Researchers isolate intact tumor microRNAs using antibody-conjugated nanowires
A research team in Japan has developed an efficient and minimally invasive cancer detection device that uses high-performance zinc oxide nanowires to selectively capture extracellular vesicles (EVs) from bodily fluids.
Novel report uses two-eyed seeing to bridge Indigenous health knowledge
A novel study among Indigenous communities in Canada utilizing sharing circles as the primary method of qualitative data collection shows that heart health is shaped by emotional, spiritual, social, and…
Scientists reveal how cGAS-STING fuels brain inflammation and neurodegeneration
The cGAS-STING pathway is emerging as a key driver of chronic neuroinflammation through its effects on glial activation, neuronal stress, blood-brain barrier integrity, and type I interferon signaling. The review…
A hidden immune pathway may help explain why Alzheimer’s inflammation persists
Researchers found that KAT7 promotes CMPK2-driven mitochondrial DNA release in microglia, activating inflammatory cGAS-STING and NLRP3 pathways linked to Alzheimer’s disease.
Researchers uncover immune loop driving Sjögren’s disease progression
Sjögren's disease is a widespread chronic autoimmune disorder that attacks the body's own glands, yet its underlying disease mechanisms remain poorly understood.
Researchers identify genetic cause of severe childhood lung disease
A new report in the American Journal of Human Genetics describes a novel disorder caused by biallelic loss-of-function variants in the TMEM63B gene, which results in severe lung disease.
Low-methionine diet shows promise against aggressive brain tumors
An unexpected lab observation led a team of scientists to discover how diet can influence survival in animal models of glioma, one of the most aggressive and deadly forms of…
Western diet weakens the gut’s nervous system through iron-dependent damage
A JCI study found that exposure to a Western diet in mice and to palmitic acid in murine and ex vivo human enteric nervous system models triggered ferroptosis, characterized by…
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