One of the uncomfortable truths about multiple sclerosis is that the part of the brain likely to reveal the most about the disease and how a patient will be impacted has been mostly invisible to clinicians.

An artificial intelligence system that operates like a collaborative team of medical experts could accelerate clinical trial design, one of the most difficult steps in drug development, according to a new study by Weill Cornell Medicine investigators.

A new review was published in Volume 13 of Oncoscience on May 22, 2026, titled "Adaptor proteins regulating tumor-associated macrophage polarization during cancer progression."

A new study published in JMIR XR and Spatial Computing demonstrates that the way virtual reality therapeutics (VRx) are introduced to patients is a critical factor in how successfully they adopt the technology.

Under an FDA ruling that expands access to clinical trials, HonorHealth Research Institute is one of the first in the nation to offer a new drug, Daraxonrasib, that based on early data nearly doubles the average survival time of patients with pancreatic cancer.

Researchers at the Icahn School of Medicine at Mount Sinai have been awarded a five-year, $7.2 million grant from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), to establish a new Asthma and Allergic Diseases Cooperative Research Center focused on advancing personalized treatment strategies for peanut allergy.

Researchers discovered that a potential drug developed at Michigan Medicine treats severe fatty liver disease by improving gut health, according to a study published in The Journal of Clinical Investigation.

According to the World Health Organization, cardiovascular diseases claim almost 20 million lives every year and remain the leading cause of death worldwide.

Researchers at the University of Colorado Anschutz have developed a promising nonhormonal therapy for women experiencing Genitourinary Syndrome of Menopause (GSM).

Cancer remains notoriously difficult to treat, partly because tumors co‑opt their surrounding environment, including the resident microbiota, to evade immune surveillance and resist conventional therapies.

Researchers have identified the brain circuitry that links deep sleep with the release of growth hormone, revealing how the two regulate each other. The newly discovered feedback loop helps explain why poor sleep can interfere with growth, muscle repair, fat metabolism, and brain function. Understanding this system could pave the way for new therapies for sleep disorders and diseases tied to metabolism and the brain, including Alzheimer's and Parkinson's.

For decades, pancreatic cancer has been one of the most lethal cancers, with few effective treatment options. A new drug, daraxonrasib, targets the KRAS mutation that fuels most pancreatic tumors—something many scientists once thought couldn't be done. In a major clinical trial, the treatment nearly doubled survival for patients with advanced disease and reduced the risk of death by 60%.

A surprising new study suggests that when it comes to pancreatic cancer, the kind of fat you eat may matter more than how much. Researchers found that oleic acid—the main fat in olive oil and several other common foods—sped up tumor growth in mice predisposed to pancreatic cancer, while omega-3-rich fats from fish oil dramatically slowed disease development.

Deep sleep does far more than rest the body — it activates a powerful brain-driven system that controls growth hormone, fueling muscle and bone strength, metabolism, and even mental performance. Scientists have now mapped the neural circuits behind this process, uncovering a delicate feedback loop in which sleep boosts growth hormone, and that same hormone helps regulate wakefulness.

Scientists have identified a crucial molecular switch that decides whether pancreatic cancer cells resist chemotherapy or respond to it. The key player, a gene called GATA6, keeps tumours in a more structured and treatable form—but it gets shut down by an overactive KRAS-driven pathway. When researchers blocked that pathway, GATA6 levels rebounded and cancer cells became more sensitive to chemo. The discovery could help turn some of the toughest pancreatic tumours into ones doctors can better control.

Researchers have discovered how pancreatic cancer reprograms its surroundings to spread quickly and stealthily. By using a protein called periostin, the tumor remodels nearby tissue and invades nerves, which helps cancer cells travel and form metastases. This process also creates a tough, fibrous barrier that makes treatments less effective. Targeting periostin could help stop this invasion before it starts.

Pancreatic cancer uses a sugar-coated disguise to evade the immune system, helping explain why it’s so hard to treat. Northwestern scientists discovered this hidden mechanism and created an antibody that strips away the tumor’s protective signal. In animal tests, immune cells sprang back into action and tumors grew much more slowly. The team is now refining the therapy for future human trials.

Researchers found that pancreatic pre-cancer cells mimic dementia by forming clumps of proteins due to faulty recycling processes. These insights could shed light on why pancreatic cancer develops so aggressively and why it is difficult to treat. By studying overlaps with neurological diseases, scientists hope to identify new strategies for prevention and treatment.

UC Berkeley researchers mapped the brain circuits that control growth hormone during sleep, uncovering a feedback system where sleep fuels hormone release, and the hormone regulates wakefulness. The discovery helps explain links between poor sleep, obesity, diabetes, and cognitive decline, while opening new paths for treating sleep and metabolic disorders.

MIT engineers have developed a tiny implantable device that could revolutionize emergency treatment for people with Type 1 diabetes. The device contains a powdered form of glucagon and can be remotely triggered—either manually or automatically by a glucose monitor—to release the hormone when blood sugar drops too low. This offers a potentially life-saving safety net, especially during sleep or for young children.

Cryptic peptides, which are expressed in pancreatic cancer cells, could be promising targets for T-cell therapies that attack pancreatic tumors, according to a new study.

Scientists say they have determined that low blood sugar, or hypoglycemia, may promote a breakdown of the blood-retinal barrier, an important boundary that regulates the flow of nutrients, waste and water in and out of the retina.

Scientists have found a way to 'intercept' pancreatic cancer. By inhibiting the cancer gene FGFR2, they were able to slow tumor formation. By targeting the FGFR2 and EGFR proteins, they were able to prevent pancreatic cancer from forming in the first place.

Adding immunotherapy to new KRAS inhibitors boosted responses in preclinical models, setting the stage for future trials of the combination strategy.

A Japanese study has found that the use of continuous glucose monitoring (CGM) devices, equipped with sensors that alert diabetics when their blood sugar levels drop, can potentially make diabetic drivers safer on the road. Those who used the devices had lower incidences of low blood sugar and reported increased confidence in driving.

Pancreatic cancer (PC) is the worst prognosis cancer globally, with just 13% of patients who are diagnosed with PC surviving for 5 years or more after initial diagnosis. Early detection of PC is the primary concern of most PC research, as it has the potential to make a substantial difference to the treatment and survival of patients. Survival rates, however, remain poor due to the vague nature of the symptoms associated with early-stage PC, and subsequently the late-stage of the disease at diagnosis. Now researchers are focusing on pancreatic cystic lesions to tackle the crucial issue of identifying patients who are at high-risk of developing pancreatic cancer, to improve survival rates.

Researchers have proven that antibiotic-resistant strains of a harmful bacteria thrive in a diabetic infection environment.

A new blood test could help doctors detect pancreatic cancer earlier, potentially improving survival rates for one of the deadliest cancers.

People with type 1 diabetes require continuous insulin treatment and must regularly measure their glucose levels. With open-loop therapies, insulin administration is manually controlled, while hybrid closed-loop systems automatically regulate insulin delivery. A study showed that hybrid closed-loop systems offer improved long-term blood sugar values (HbA1c levels) and a lower risk of hypoglycemic coma, but lead to a higher rate of diabetic ketoacidosis.

Pancreatic cancer patients may benefit from future precision treatments as a new study shows how some tumors may potentially be more susceptible to macrophage-based therapies, and clues behind why these tumors don't respond to existing immunotherapies.

A team of scientists has used a novel approach to identify protein degraders that target Pin1, a protein involved in pancreatic cancer development.

The discovery of a gut-to-brain regulation pathway in flies calls for additional consideration on how certain medications, especially GLP-1 agonists, can be used to treat obesity and diabetes in humans.

People with diabetes take insulin to lower high blood sugar. However, if glucose levels plunge too low -- from taking too much insulin or not eating enough sugar -- people can experience hypoglycemia, which can lead to dizziness, cognitive impairment, seizures or comas. To prevent and treat this condition, researchers report encapsulating the hormone glucagon. In mouse trials, the nanocapsules activated when blood sugar levels dropped dangerously low and quickly restored glucose levels.

Staging of patients with early pancreatic cancer is inaccurate as much as 80% of the time, according to a new study. The finding underscores the urgent need for advancements in diagnostic technology and staging, which could significantly alter early pancreatic cancer treatment and research.

Research in mice sheds light on how thyroid hormone alters wiring in the brain. Findings reveal that thyroid hormone syncs up the brain and body to drive exploratory behavior. Researchers say their work could illuminate new treatments for certain psychiatric conditions.

Researchers found a 'neuro-cancer axis' may promote spread of breast cancer. They also found that an FDA-approved anti-nausea medication may prevent it.

Scientists created new tools to study brain messenger proteins called neuropeptides in the brains of behaving animals, discovering they are the primary messengers in the fear circuit in mouse brains, and that multiple neuropeptides work together to achieve this--explaining why some clinical trials that target just one neuropeptide have failed. The new tools and findings can be used to direct drug development for fear-related neurological disorders like PTSD and anxiety, design better painkillers, and uncover new information for other neural circuits in the brain.

Researchers have developed a 3D genomic profiling technique to identify small precancerous lesions in the pancreas -- called pancreatic intraepithelial neoplasias (PanINs) -- that lead to one of the most aggressive, deadly pancreatic cancers.

An international research team has discovered a new way to effectively treat cancer, by using nutrients to reactivate suppressed metabolic pathways in cancer cells.

The cost of nutritious food and the lack of access to it are of significant concern to U.S. consumers. New public opinion poll and expert analysis reflect crucial need to make healthy food accessible to avert projected crisis in cardiovascular disease incidence, costs.

One of the most confusing aspects for patients with type 2 diabetes mellitus is that they have high fasting glucose levels. This is because in these insulin-resistant patients, glucose production by the liver is triggered, a process that is still full of questions for the scientific community. Now, a review article presents a comprehensive overview of the most important advances in understanding this mechanism.

Scientists developed a human pancreatic cancer fibrotic barrier 3D cell-culture model to assess treatments for pancreatic ductal adenocarcinoma. By targeting the ROCK2 pathway, they achieved a notable decrease in fibrosis and enhanced tissue permeability to drugs, offering promising avenues for overcoming treatment obstacles in pancreatic cancer.

Neuropathy, the nerve damage that causes pain and numbness in the feet and hands and can eventually lead to falls, infection and even amputation, is very common and underdiagnosed, according to a new study.

Older people may be at greater risk of developing pancreatic cancer and have poorer prognoses because of age-related changes in cells in the pancreas called fibroblasts, according to new research.

Based solely on driving behavior and head/gaze motion, the newly developed tool recognizes low blood sugar levels.